journal of kerbala university

Abstract

Sixty seven patients with prooved carcinoma of the urinary bladder in Babylon Governorate and show changes in their glutathione-S-transferase (GST) and reduced glutathione (GSH) in the blood. The studied patients were (57) males and (10) females and the control group was (36).The mean age of the patients was (55) years old,68% were exposed to chemicals,46% of patients had history of urinary stones,84% were smokers and 91% presented with negative family history of tumors.The results of the study were:both GST and GSH in the blood decrease in bladder cancer,exposure to chemicals had affected both GST and GSH,urban and rural areas had nearly the same incidence of cases,GST is affected by testosterone while GSH is affected by estrogen and the size of the tumor affected both GSH-and GST.It is concluded that bladder cancer affects GST and GSH levels in the patients' blood.Gender,smoking,exposure to chemicals and age had a signifecant effect on blood levels of GST and GSH.