journal of kerbala university

Abstract

The biological activity of some nickel (II) complexes containing mixed ligands {having the formulaes [Ni2(Sch)2(Py)4(NO3)2](NO3)2 and [Ni2(Sch)2(Py)4(NO3)3]NO3 (where Sch=benzaldehyde semicarbazone - Bsch or 2-fluorobenzaldehyde semicarbazone - Fsch; Py = substituted pyridine: 2-aminopyridine - Py1, 4-aminopyridine – Py2, 2,3-dicarboxypyridine - Py3, 2-amino-3-hydroxypyridine - Py4, 2-amino-4-methylpyridine - Py5 or 3,4-dicarboxypyridine - Py6 )} in dimethylsuphoxide solutions(DMSO) have been evaluated by agar plate diffution technique against five human pathogenic bacterial strains: Bacillus subtilis, Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa and Proteus vulgaris . The complexes were found to have antimicrobial activity on some gram-positive and gram-negative bacteria, in vitro. The effective concentration ranging between 62.5-500 µg/ml. Pseudomonas aeruginosa were the most sensitive bacteria followed by Staphylococcus