Synthesis of the new carbohydrate Ibuprofen ester as possible prodrug
journal of kerbala university,
2007, Volume 3, Issue 4, Pages 4-10
AbstractSynthesis of new ibuprofen ester (5) is described . Ester formation was achieved by esterification of the ibuprofen carboxylic acid (1) with diacetone fructose (3) The structure of synthesized compounds were characterized by means of FTIR and UV, Preliminary results showed that the prepared fructose-drug conjugates underwent hydrolysis and released the pound ibuprofen and fructose. However, detailed kinetic studies of chemical and potential enzyme hydrolysis still remain to be down.
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