Determination of Oxidative Stress and Antioxidant System in Chronic Obstructive Pulmonary Disease (COPD
journal of kerbala university,
Volume 4, Issue 3, Pages 219-223
AbstractAirways are exposed to high levels of environmental oxidants, yet they also have enriched antioxidants. Airways disease such as chronic obstructive pulmonary disease (COPD) has evidence of increased oxidative stress and decreased antioxidants.The aim of this study was to examine oxidant/ antioxidant status in 45 patients with COPD (Age range: 30 to 50 years) and in (40) healthy subjects. The status of oxidants in serum as represented by malondialdehyde (MDA) levels increased significantly (p<0.01) in the conditions of chronic obstructive pulmonary disease (COPD), than their controls, also, non-enzymatic antioxidants (vitamin E, albumin and uric acid) which protects the lung from increased oxidative stress, were estimated in both of patients and controls groups. Vitamin E levels in patients with COPD were found to be significantly lower (p<0.01) as compared to control, On the other hand, low serum albumin (p<0.001) and uric acid levels were observed in the study group than controls. The changes in oxidant/ antioxidant status may be the effect of chronic obstructive pulmonary disease state.
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