Possible Correlation between Helicobacter pylori and Duodenitis in Non-ulcer Dyspeptic Iraqi Patients.
journal of kerbala university,
Volume 4, Issue 3, Pages 203-209
AbstractIn this study, we have attempted to show the relations between degrees of duodenal mucosal inflammation in biopsy specimens from non-ulcer dyspeptic (NUD) patients with the presence of anti–Helicobacter pylori (H.pylori) IgG. For this purpose, duodenal biopsies, taken during orogastroduodenoscopy, and sera were obtained from 42 consecutive NUD patients. Anti –H.pylori IgG levels in those patients were determined using ELISA and correlated with histopathological findings. Five cases (11.9%) have demonstrated normal mucosa without any sign of inflammation. Mild inflammation was shown in 26 patients (61.9%) while sever inflammation was shown in 11 cases (26.2%). A positive correlation was found between presence of anti- H.pylori IgG and degree of inflammation of the duodenal mucosa (r = 0.306, p= 0.049). However, no correlations could be found with either the histological changes of the duodenal villi and endocopical findings. These results may indicate a causal relationship between H.pylori and duodenitis in nonulcer dyspeptic patients and, moreover, may implicate duodenitis as an important etiological cause of NUD.
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