Protective Role Of Curcumin On some of oxidative stress parameters and cerebrum Tissue In Male Rabbits Subjected To Monosodium Glutamate
journal of kerbala university,
2017, Volume 13, Issue 3, Pages 11-22
AbstractThis study aimed to know the preventive role of a substance Curcumin . against damage happening in the nervous system and induced textured monosodium glutamate (MSG) in male rabbits., sixty of adult male rabbits were randomly divided into four equal groups (15 animals / group), the first group (G1) intubated with 1 ml / kg ml / kg of corn oil and served as a control group (G1). The second group were intubated orally and daily with 3mg /kg of MSG for three months , while the third group (G3) has intubated orally and daily with 60 mg / kg curcumin for three months , the fourth group intubated orally and daily with 3mg /kg of MSG and 60 mg / kg of curcumin for three months .Fasting blood samples were collected from fasted rabbits at pretreated period , Mid-experiment and at the end of experiment to study the following parameters: concentration of Malondialdehyde (MDA) , Reduced Glutathion (GSH) and peroxy nitrite ( ONOO ( _ . The results revealed that oral dosing with MSG caused a significant decrease (P <0.01)in rate of GSH compared with control group and significant increase (P < 0.01) in rate of MDA , ONOO _ compared with the control group. The group that treated with 60mg/kg curcumin revealed a significant increase (P <0.01) in GSH concentration compared with the control group and a significant decrease (P <0.01) in the concentration MDA and ONOO _ compared with the control group. Experience also shows that oral dosing with MSG and curcumin caused no significant difference(P <0.01) was observed in the concentration GSH ,MDA and ONOO _ compared with the control group.
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