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Effect of alkaloid compounds toxicity extracted from potato tuber on lethal dose of male albinus rats
journal of kerbala university,
Volume 11, Issue 2, Pages 87-95
This study was conducted in Biology Department/ College of Science/University of Kufa to detect the active ingredients and separation of alkaloids compounds from potato tubers (Bentiji cv.) and their effects on lethal dose of white male rats.
Alkaloids were determined in different potato tuber samples. It was found that there are 130 mg/kg. fresh weight( F.W. )from normal tubers, 340 mg/kg. F.W. from large tuber that partially greened and 870 mg/kg. F.W. from small size tubers which are completely green . Besides, it was found that alkaloid percentage condensed on the external surfaces (peel) that reached 888 mg/kg. F.W. compared with 140 mg/kg. F.W. from the internal part (flesh).
Lethal Dose (LD50) was done for both crude and alkaloid tuber extracts for the studied rats that orally administrated with the above extracts(with different conc.). It was found that alkaloid extract was more toxic than crude potato extract. It was 575 and 850 mg/kg. for alkaloid and crude potato extract, respectively.