ISSN: 1813-0410

Keywords : FasL


Effect of dietary supplementation of crushed seed of Coriander Coriandrum sativum on Some Physiological & Immunological parameters of broiler Hubbard flex.

journal of kerbala university, Volume 9, Issue 1, Pages 194-201

The present study has been aimed to determine the positive effect that can be detected by crushed seed of Coriander Coriandrum sativum addition to the broilers diet on some physiological & immunological parameters. One hundred and fifty broiler chicks of one day age, were randomly divided into three equal groups. First group (control) fed on the standard provender along the experimental period (42 days), second group (T1) fed on standard provender supplemented with 2.5%, third group (T2) fed on standard provender supplemented with 5%. At the end of experiment, body weight was recorded and blood samples were obtained from wing vein for estimation of white blood cells counts, differential leukocytes counts, Phagocytosis activity for neutrophil and monocytes. Total protein, globulin, glucose, total cholesterol, IgG, IgA & IgM concentrations in blood serum were calculated. Then, birds were sacrificed and the liver, kidneys and spleen obtained for histological measurement. The result revealed that crushed seed of Coriander Coriandrum sativum supplementation in the two treated groups caused a significant increase (P<0.05) in body weight & weight of liver when compared with control group. The result revealed that the second and third groups were significantly (P<0.05) recorded higher values in their white blood cells counts, Lymphocytes, Monocytes counts & Phagocytosis activity. At the same time, the result of total protein & globulin showed a significant increase (P<0.05) in two treated groups compared with control. On the other hand, serum concentration of glucose and cholesterol showed a significant decrease (P<0.05) in the two treated groups compared with control. At the same time, the result of IgG & IgA concentrations, revealed a significant increase (P<0.05) in IgG & IgA concentrations in the both T1 and T2 groups compared with control.

Expression of death receptor (Fas) , and it's specific ligand (FasL)in transitional cell carcinoma of the urinary bladder.

journal of kerbala university, Volume 1, Issue 0, Pages 98-105

This study was designed by using 36 paraffin embedded tumor tissues obtained from TCC patients, and 10 normal bladder tissues obtained from forensic medicine institute.
All specimens undergone to in situ hybridization technique for in situ mRNA expression detection of Fas and Fas L ; results of this study reveled that a high significant expression in malignant tissues compaired with normal tissues (p< 0.05 ), (P > 0.05) respectively .Moreover ,FasL expression on transitional malignant cells has a linear increase with tumor grade and stage progression ; there was a significant difference in FasL expression between grade I and grade III(P < 0.05) and between stage T1 and T2 (P < 0.05) . while we found an inverse relation between Fas expression on these cells and tumor grades and stages progression ; there was a significant difference among grades and among stages (P < 0.05) , (P < 0.05) respectively. while there was no significant differences in Fas /FasL expression on lymphocytes and tumor grade and stage progression (P>0.05), (P>0.05) respectively.
A highly significant liner relation was showed between Fas L expression on transitional malignant cells tumor grade and stage progression (p<0.01) , (p<0.01) respectively .
From this study we conclude that overexpression of FasL are correlated with TCC invasion and progression.