Keywords : Pregnancy
journal of kerbala university,
Volume 11, Issue 0, Pages 91-99
The present study based essentially to estimate correlations of available clotting factors involved in extrinsic, intrinsic, and common pathway and estradiol hormones of pregnant women. Women were included, in this study of these, (60) women were pregnant and sub divided into three groups according to phases of pregnancy (20) women at first trimester, (20) women at second trimester, and 20 women at third trimester). Twenty five (25) women were also recruited in this study and used as control group (non-pregnant and non-lactating). All ages of women were ranged between 20–35 years old. Concerning estradiol hormone concentrations in pregnant women, it have been found that the levels of estradiol hormone were insignificantly increased (p>0.05) during first trimester and significantly elevated (p<0.05) throughout second and third trimester in a comparison with control group. Data obtained from the present study indicated a progressive elevation (p<0.05) in the levels of fibrinogen (FI) concentrations throughout pregnancy period, and its concentrations confirmed a significant positive correlation (r = 0.825) with estradiol concentrations. Levels of prothrombin (FII) activities in pregnant women were significantly higher (p<0.05) than of non-pregnant and these activities correlated positively (r = 0.643) with estradiol level. Results of factor FVII activities (major component of extrinsic pathway) were insignificantly elevated (p>0.05) during first and second trimesters and tend to be progressively increased (p<0.05) during third trimester and confirmed a positive correlation (r = 0.523) with estradiol levels.
Determination of major components of intrinsic pathway including FVIII and FIX. Their activities seen to be progressively increased (p<0.05) throughout periods of pregnancy and recorded a positive correlation (r = 0.375, r = 0.538, respectively) with levels of estradiol hormone. In conclusion, data obtained from this study and mentioned above may be due to increased efficiency of various clotting factors involved in different clotting pathway parallel with progress of gestation because of heightened levels of estradiol hormone, and these excessive activities tend to exert protective mechanism to prevent excessive blood loss during expulsion of placenta.