Keywords : VLDL
journal of kerbala university,
Volume 5, Issue 3, Pages 346-353
Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factor. Lipid profiles are potent markers for cardiovascular risk.
Aim of the study:
To identify changes in lipid metabolism in women with PCOS and the relative impact of obesity and hyperandrogenism on lipid parameters.
Subject and methods:
The study was conducted in the period from August 2006 till March 2007 on eighty women, who had been diagnosed as PCOS; they were recruited from IVF Institute of Embryo Research &Infertility Treatment in Baghdad. Twenty apparently healthy fertile women were served as control. Endocrine evaluation and Lipid assays were performed in both cases and controls.
There were significant elevations in LH, LH to FSH ratio, Testosterone and Free testosterone levels in women with PCOS when compared with the normal control group.
For lipid profile there was a significant elevation in levels of TG, Cholesterol, and LDL in combination with low level of HDL and with an increase in atherogenic index in women with PCOS when compared with normal control group.
Amore atherogenic lipid profile, in particular related to HDL metabolism, was found in women with PCOS, both obesity and hyperandrogenism contribute to these changes, and there was evidence for an additional influence of PCOS on lipid metabolism.