Keywords : Rats
journal of kerbala university,
Volume 10, Issue 0, Pages 87-94
There is growing evidence that oxidative stress and estrogen deprivation after menopause or ovariectomy represent two main risk factors closely related to the development of Alzheimer’s disease .The aim of this study was to evaluate the effect of ovariectomy on some oxidative stress markers and pathological lesions in the cerebellum of adult rats. Twenty rats were randomly divided into two groups (10/group) control(C) and overctomized group (OVX).After three months estimated levels of Malondialdehyde( MDA), Nitroxide (NO) and glutathione peroxidase (GPX) in the serum and cerebellum and sections of the cerebellum was removed histopathologial study . The results Showed a significant increase (P<0.05)in the ( MDA), (NO) and (GPX) levels and significant decrease(P<0.05) in (GSH) level and(CAT) activity in the serum and cerebellum tissue of the overctomized group compare with that in the control group . The microscopical examination was shown in the cerebellum tissue in the overctomized group characterized by decrease in the purikinje and granular cells in the gray matter . Vacuoles were present in the white matter with microglial cells infiltration in the pia mater .For conclusion The overctomy in adult rats an showed increase in the oxidative stress markers and pathological lesions in the gray and white matters in the cerebellum .