Keywords : Insulin
Relation of Antioxidant Vitamins (A, E, C) with Insulin Level and Selenium in Diabetic Patients Type 2
journal of kerbala university,
2011, Volume 7, Issue 2, Pages 1-6
Free radicals have important role in the pathogenesis of diabetes mellitus. In diabetes, free radical production is increased whereas capacity of antioxidant system is reduced. In the present study we determined and evaluated changes in levels of selenium and antioxidant vitamins (A, E, C) in serum of patients with Diabetes Mellitus type 2. Total of 200 diabetic patients (110 male, 90 female) with mean age of 47.52±8.46 years were recruited into the study. Control group was composed of 150 healthy volunteers (102 male, 48 female) with mean age of 48.31±11.99 years. In addition to aforementioned parameters, levels of fasting blood glucose, hemoglobin A1c (HbA1C) levels were determined in diabetic patients and controls. There was a significant increase in insulin level, highly significant decrease in antioxidant vitamin level (A, E, C) and highly significant decrease in selenium level. On the other hand negative correlations (p<0.0001) were found between fasting serum insulin level and vitamin A and positive correlation between serum insulin level and vitamins C and E while there is highly positive correlation between serum selenium and vitamin A(p<0.01) and negative correlation between serum selenium level and antioxidant vitamins C and E (p<0.05).
In conclusion supplementation of antioxidant vitamins into the daily diets of diabetic patients with type 2 will enhance power of non-enzymatic antioxidant defense systems.