ISSN: 1813-0410

Keywords : kinetics

Thermodynamic and kinetic studies for the interaction of cephalexin with albumin

Elham M.Al-Rufaie; Alaa Abd Al-Zahra; Alaa j.khadim

journal of kerbala university, 2015, Volume 11, Issue 2, Pages 80-89

This work aim to get information about the binding of cephalexin(antibiotics) with albumin, and the influence of the solvent polarity and ionic strength on it by using UV-visb spectrophotometric measurements in phosphate buffer solution pH (7.4), and at three different temperatures, (290, 300, 310)K .The UV absorption shows a change and a shift in the absorbency and a shift in albumin and cephalexin peaks, the two changes are indicative of complex formation. The stoichiometry of the interaction were calculated by the method of continuous variations which was1:1at pH 7.4.The equilibrium constant was calculated at three different temperature (290,300,310)K and the thermodynamic parameter such as ∆G, ∆H and ∆S also calculated. The kinetic studies for this interaction follows first order equation with a rat constant value of 13.8×10-4 min-1.

Kinetic and thermodynamic studies for the adsorption of Nickel (II) by Basil seeds in aqueous solutions

Elham M . AL-Rufaie; Beidaa A.kadhim

journal of kerbala university, 2015, Volume 11, Issue 1, Pages 135-145

Environmental pollution as a result of a heavy metal presence led to serious health problems. Inthis study, the adsorption by swollen Basil seeds were determined. The adsorption behavior of Basil seeds with respect to Nickel (II) has been studies by batch method to consider its application in this field.The effects of various experimental parameters like contact time, dosage of Basil seeds, initial concentration of the metal ion, pH of solution, and temperature have been investigated .The removal percentage is a pH dependent and decrease with increase in temperature, The best removal were at 200C. The equilibrium adsorption experimental data were found to fit Freundlich isotherms for Nickel (II). The pseudo-first and second order kinetic model both fitted the kinetic.The thermodynamic parameters, (∆0G) was found to be positive and become negative at low temperature (below 100C), ∆0H is negative that means exothermic adsorption process and ∆0S is negative also which indicate the increase in the order at the solid-solution interface.