Keywords : Cholesterol
journal of kerbala university,
2009, Volume 5, Issue 3, Pages 346-353
Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factor. Lipid profiles are potent markers for cardiovascular risk.
Aim of the study:
To identify changes in lipid metabolism in women with PCOS and the relative impact of obesity and hyperandrogenism on lipid parameters.
Subject and methods:
The study was conducted in the period from August 2006 till March 2007 on eighty women, who had been diagnosed as PCOS; they were recruited from IVF Institute of Embryo Research &Infertility Treatment in Baghdad. Twenty apparently healthy fertile women were served as control. Endocrine evaluation and Lipid assays were performed in both cases and controls.
There were significant elevations in LH, LH to FSH ratio, Testosterone and Free testosterone levels in women with PCOS when compared with the normal control group.
For lipid profile there was a significant elevation in levels of TG, Cholesterol, and LDL in combination with low level of HDL and with an increase in atherogenic index in women with PCOS when compared with normal control group.
Amore atherogenic lipid profile, in particular related to HDL metabolism, was found in women with PCOS, both obesity and hyperandrogenism contribute to these changes, and there was evidence for an additional influence of PCOS on lipid metabolism.
journal of kerbala university,
2006, Volume 2, Issue 2, Pages 102-121
Background: Cholesterol is widely distributed in all tissues, but it is especially abundant in the nervous system, where it is important for many aspects of cellular structure and function. Depression is present in high range in patients admitted to hospital after a myocardial infarction and is an independent risk factor for increased mortality. Cholesterol is one of the risk factor of ischaemic heart diseases (IHD). Any association between depression and cholesterol level is complex and may be confounded by the increase use of antidepressants and other medications among persons with depression.
In this work, an attempt was carried out to link depression, serum cholesterol, and the effect of treatment by measuring serum cholesterol in the tricyclic antidepressants (TCAs) treated depressed patients and compare with control and untreated depressed patients to evaluate the effect of treatment
on serum cholesterol. The second aim of this study is to review the majority of researches that studied serum cholesterol in different categories of depressed patients in different countries.
Patients and Methods: This study included (38) depressed patients who are on TCAs as one of the drugs prescribed for the treatment. The second group consists of seventy two untreated depressed patients. Fifty apparently healthy subjects (no depression and IHD) were selected as a control group. Their sex and age were comparable to those of patients.
Total serum cholesterol was measured by using enzymatic method for the trhree groups under study. Results: There is a significant decrease (p<0.05) in mean serum cholesterol in untreated depressed patients as compared with control or treated depressed patients. While no significant changes noticed from the comparison between treated depressed patients and control group. The results showed that there is a significant difference between males and females in control and untreated depressed patients groups while there is no significant difference in serum cholesterol in between male and female in Treated Depressed Patients.
Conclusion: From the results of this research and the review, it can be concluded that:
Depression is not yet a consistent risk factor for IHD. Low cholesterol in suicide patients (usually severely depressed) can be predicted by a severe decline in appetite and cease of food ingestion. Therefore, cholesterol levels in their serum should be decreased.
Treatment with TCAs results in improvement in depression symptoms, including appetite, but has bad side effects on heart. Hence, the diagnosed depressed patients, who already under treatment, have a higher risk of IHD than control. In those groups of depressed patients, serum cholesterol will be normal or higher than the baseline, but they have a higher risk of IHD.