ISSN: 1813-0410

Keywords : Thesis


Effect of alkaloid compounds toxicity extracted from potato tuber on lethal dose of male albinus rats

journal of kerbala university, Volume 11, Issue 2, Pages 87-95

This study was conducted in Biology Department/ College of Science/University of Kufa to detect the active ingredients and separation of alkaloids compounds from potato tubers (Bentiji cv.) and their effects on lethal dose of white male rats.
Alkaloids were determined in different potato tuber samples. It was found that there are 130 mg/kg. fresh weight( F.W. )from normal tubers, 340 mg/kg. F.W. from large tuber that partially greened and 870 mg/kg. F.W. from small size tubers which are completely green . Besides, it was found that alkaloid percentage condensed on the external surfaces (peel) that reached 888 mg/kg. F.W. compared with 140 mg/kg. F.W. from the internal part (flesh).
Lethal Dose (LD50) was done for both crude and alkaloid tuber extracts for the studied rats that orally administrated with the above extracts(with different conc.). It was found that alkaloid extract was more toxic than crude potato extract. It was 575 and 850 mg/kg. for alkaloid and crude potato extract, respectively.

Effect of potato tuber alkaloid extract cocenteration and dosage period on oragan weights of Albinus rats

journal of kerbala university, Volume 11, Issue 2, Pages 79-86

The study was conducted in Biology Department/ College of Science/University of Kufa to detect the active ingredients and separation of alkaloids compounds from potato tubers (bentji cv.) and dosage period on animal , Liver, Kidney and Spleen weights for white male rats.
This experiment was conducted to study the effect of different alkaloid concentration extracts on animal, liver , kidney and Spleen weights. Weights of treated animals decreased gradually with the increase in the alkaloid concentration. and length of dosage period. The opposite was found for the weights of liver, kidney and spleen which were 7.66 ,1.17 ,0.67 g . with the interaction of 200mg/kg and four weeks treatment compared to 2.66 ,0.25 and 0.45 g with control treatment for liver,kidney and spleen ,respectively.