ISSN: 1813-0410

Keywords : Flow injection analysis


A new Approach for the Turbidimetric Determination of Cyproheptadine Hydrochloride in Pharmaceutical Preparations by Using Homemade Linear Array Ayah 6SX1-T-2D Solar cell CFI Analyser

Nagam S.Turkey Al-Awadie; Kefah H. Ismael Al-saadi

journal of kerbala university, Volume 11, Issue 1, Pages 61-80

A new turbidimetric – flow injection method is described for the determination of Cyproheptadine hydrochloride(CPH-HCl) in pure and pharmaceutical preparations .The method is characterized by simplicity ,sensitivity and speed ,it is based on formation of ion-pair between CPH-HCl and hexacyanoferrate (III) in aqueous medium to form yellow precipitate .This precipitate was determined using homemade Ayah 6SX1-T-2D Solar cell-CFI Analyser via the reflection of incident light from the surfaces precipitated particles at (0-180°) .Chemical and physical parameters were studied and optimized .The calibration graph was linear in the range of 0.5- 10 mmol.L-1 , with correlation coefficient r = 0.9785 ,while the percentage linearity (%r2) was %95.75 .The limit of detection (S/N=3) 280.72 ng /100 µL from the stepwise dilution for the minimum concentration in the calibration graph with RSD lower than %1.5 for 5and 7 mmol.L-1 (eight replicates ) concentration of CPH-HCl .The method was successfully applied for the determination of CPH-HCl in three different companies of pharmaceutical drugs . A comparison was made between the newly developed method analysis with classical method (HANNA instrument for turbidity measurement) using standard addition method via the use of t-test and F-test ,it was found that there was no significant difference between two methods at %95 confidence level .

Determination of Bismuth (III) ion by continuous flow injection analysis via turbidimetric (T180o) and scattered light effect at two opposite position (2N90o ) using Ayah 4SW-3D-T180o -2N90o -Solar - CFI Analyser

Nagam S. Turkey Al-Awadie; Ahmed F. Khudhair

journal of kerbala university, Volume 10, Issue 0, Pages 182-198

A simple and highly sensitive method for the determination of Bi(III) ion was developed by continuous flow injection analysis via turbidimetric (T180o) and scattered light effect at two opposite position (2N90o). The formation of a black precipitate is based upon the reaction between Bi(III) with SnO22- in basic medium. The precipitate is measured via the attenuation of incident light and it’s scattering in two opposite directions. Chemical and physical parameters were studied to obtain the best condition . The linearity of Bi(III) ion is ranged from 0.08 to50mmol.L-1, with correlation coefficient r=0.9973, limit of detection (LOD) 0.06 mmol.L-1(3SB)(S/N=3) and the percentage relative standard deviation for 45 mmol.L-1 Bi(III) solution is lower than 3% (n=6). This method has been applied successfully to determine a bismuth ion in drug. Also provided a comparison between the new method with the classical method (spectrophotometric method) of analysis using the standard addition method. It shows that there was no significant difference via the use of paired t- test at α=0.05(95% confidence) between the two methods and could be using the develop method as an alternative method.

Spectrophotometric-Continuous Flow Injection Analysis(S-CFIA) For The Determination of Cobalt(Π) Ion in River&Alloy Samples Via The Use of 10,10-Dimethyl 9,9-Diacridinium Dinitrate Salt-Hydrogen Peroxide in Alkaline Medium

journal of kerbala university, Volume 9, Issue 1, Pages 244-258

A newly spectrophotometric analytical method characterized by it is speed and sensitivity was developed for the determination of Cobalt ions in pure, river water and alloys, using homemade continuous flow injection. The method is based on the oxidation of Lucigenin by hydrogen peroxide in alkaline medium to produced N-methyl acridine which gives with Co(Π) a red-brown color complex(λmax=405nm). Linear dynamic range for the absorbance versus Cobalt(Π) concentration was 0.0-100µg.ml-1, the percentage linearity (r2%) was 99.39%, while the L.O.D (S/N=3) was 1.2ng/sample from the step wise dilution for the minimum concentration of lowest concentration in the linear dynamic ranged of the calibration graph with L.O.Q was 6ng/sample. R.S.D% for the repeatability (n=8) was 0.6% for the determination of Cobalt(Π) with concentration of 10µg.ml-1, through put 40 sample.hr-1, sample volume 150µl. The method was applied successfully for the determination of Cobalt(Π) in different samples. A comparison was made between the newly developed method of analysis(S-CFIA) with classical of analysis using the standard addition method via the use of paired t-test. It shows that there was no significant difference at α=0.05(95% confidence interval) between the two methods. Therefore, the newly developed method can be adopted as an alternative method for the analysis of Cobalt(Π).