Author : H. Alta, Abdulsamie
journal of kerbala university,
Volume 2, Issue 4, Pages 81-89
Several studies reported that serum creatinine and serum uric acid significantly and independently associated with excess mortality of cardiovascular diseases and stroke.
The present study was done to express the relation of serum creatinine and uric acid to mortality and cardiovascular diseases in Iraqi people.Forty one patients (25 males, 16 females) with AMI admitted to Merjan Teaching Hospital in Hilla city (2005) clinically diagnosed and fifty two (25 males ,27 females) apparently healthy persons as controls subject to present study Serum creatinine was determined calorimetrically according to the reaction with basic picrate solution, whereas uric acid was determined enzymatically using uricase method. Results of present study show significant increase in the levels of serum creatinine and uric acid of patients with AMI when compared with healthy controls(P<0.05). Whereas serum uric acid/ creatinine (UA/Cr) ratio of patients with AMI found to be significantly decreased when compared with healthy controls(P<0.05). The relationship between serum uric acid and creatinine was negative correlation in patients, whereas this relationship found to be positive in healthy controls.In conclusion, serum UA/Cr ratio, serum creatinine and serum uric acid in Iraqi people patients with acute myocardial infarction AMI, may aid in the prediction of mortality of cardiovascular diseases.