Author : K. Mahmmod, Maha
journal of kerbala university,
2007, Volume 3, Issue 3, Pages 277-283
Synthesis of new ibuprofen ester (5) is described . Ester formation was achieved by esterification of the ibuprofen carboxylic acid (1) with diacetone fructose (3) The structure of synthesized compounds were characterized by means of FTIR and UV, Preliminary results showed that the prepared fructose-drug conjugates underwent hydrolysis and released the pound ibuprofen and fructose. However, detailed kinetic studies of chemical and potential enzyme hydrolysis still remain to be down.