ISSN: 1813-0410

Author : M.Ali, Angam

A study of the effect of cytokines and LPS on the growth of some pathogenic bacteria

Mahdi H. M.Al- Ammar; Angam M.Ali

journal of kerbala university, 2007, Volume 3, Issue 4, Pages 23-28

Patients with respiartory tract infection have elevated rates of proinflammatory cytokines in the lungs and circulation and increased levels of bacterial infections. Pathogenic cells activated with lipopolysacchride( LPS) that elecate a high levels of proinflammatory cytokines in monocytic cells ,are ineffeicient for killing ingested bacteria in spite of having intact pathogenic activity.Bacteria may adapt and utilize cytokines and LPS in high concentrations on their growth . A primed a monocytes cells with exessive concentrations of cytokines TNF-α ,IL-1β and IL-6 and with LPS .Then exposed to isolates of some pathogenic bacteria represented by St. pyogenes,Pseudomonas aeruginose ,and Haemophilus influenzae that cause diseases for respiratory tract .The intacellular growth were decreased with lower concentrations of proinflammatory cytokines (10-100 µg )or LPS (0.5 to 1 µg ). However , when human monocytes were primed with higher concentrations of proinflammatory cytokines (100 to 1000µg ), intacellular growth of the testing bacteria increased significally.