Author : H.Abood, Zaid
Synthesis of Some New Azo Schiff Bases and Tetrazole Derivatives from 2-Amino -1,3,4-thiadiazole-5-thiol
journal of kerbala university,
Volume 4, Issue 2, Pages 140-155
In this paper new azo schiff bases and tetrazole derivatives of 2-Amino-1,3,4-thiadiazole-5-thiol have been prepared.2-Amino-1,3,4-thiadiazole-5-thiol  was prepared by the reaction of thiosemicarbazide with carbon disulfide in alcoholic sodium carbonate solution .Compound  was converted to the diazonium salt which was directly converted to the azo derrivative  via a coupling reaction with salicyldehyde.The new azo Schiff bases derivatives [3-6] were prepared by condensation of aldehyde group of the new azo aldehyde derivative  with some primary amines ( 3-Amino phenol, 3-Bromo aniline ,2-phenyl ethyl amine ) and with 2,4- Dinitro phenyl hydrazine respectively in absolute ethanol. The resulting imines [3-6] were converted to the corresponding tetrazole derivatives[7-10] through 1,3-dipolar cycloaddition reaction with sodium azide in tetrahydrofuran. All new synthesized derivatives were identified by their melting points,elemental analysis and FT-IR spectra. They have long been known to posses hypnotics activities and it is hoped that our compounds would do so.