ISSN: 1813-0410

Author : Fahad Ali, Khalid

Synthesis of New type of tetrazoles starting from D-ribose

Khalid Fahad Ali

journal of kerbala university, Volume 4, Issue 2, Pages 33-36

This work includes synthesis of sugar tetrazole derivative, D-ribose reacted with acetone in the presence of sulfuric acid H2SO4 to give 2,3-O-isopropylidene-D-ribose (1). The Aldol condensation of (1) with formaldehyde in methanolic K2CO3 solution gave 2-hydroxymethyl(2,3-O- isopropylidene-D-ribose) (2). Which was tosylated by Tosyl chloride in pyridine to yield compound (3), SN2 reaction of (3) with sodium cyanide in DMSO afforded compound (4). The [2+3] cycloaddition reaction of (4) with sodium azide gave the targeted compound (5). All prepared compounds have been characterized by: TLC, Specific rotation, Microelemental analysis and [FT-IR and 1H NMR spectroscopy]