ISSN: 1813-0410

Author : Abdul Hussain S. AL-Janabi, Ali

A new function of Aminophylline as antidermatophytic agent

Ali Abdul Hussain S. AL-Janabi

journal of kerbala university, 2008, Volume 4, Issue 3, Pages 7-15

Aminophylline (theophylline derivative) is an important drug compound which is generally used to treat bronchoconstriction diseases for a long period of times. Dermatophytoses is the most common disease on human skin caused by many species of dermatophytes.
Aminophylline was tested against three species with two variants of Trichophyton (one genus of dermatophytes) using two methods. Those species were Trichophyton mentagrophytes var. mentagrophytes, Trichophyton mentagrophytes var.interdigitale, Trichophyton rubrum and Trichophyton simii. Aminophylline was revealed a high activity against all species of dermatophytes at concentration of 5 mg/ml with a completely inhibited of colony growth on the bases of colony diameter and dry weight measurements. The efficiency of aminophylline to inhibit fungal growth was less than theophylline. Both of aminophylline and theophylline indicated no significant differences value (P<0.01) compared with griseofulvin
(0.5 mg/ml).
Minimal inhibitory concentration (MIC) of aminophylline was also determined in this study. The MIC value of aminophylline against two species of dermatophytes was observed in 4 mg/ml.