Author : Barry.M .Mahood, Abdul
journal of kerbala university,
Volume 4, Issue 4, Pages 310-316
A simple and sensitive spectrophotometric method is described for the determination of Diclofenac sodium, in pure form and pharmaceutical formulations. The method is based on the reaction of drug with iron(III)chloride to form iron(II) which reacts with potassium hexacyanoferrate(III)forming a blue color product measurable spectrophotometrically at 710nm.Linearity was in the rang(1.00-6.00 μg. ml-1 ).A linear response was observed over the tested range of drug with correlation coefficient of 0.9980 ,a relative standard deviation of (0.396-0.934%) and recovery of(97.83 -104.9%) . The method was successfully applied to the determination of this drug in their dosage forms.