Author : Al-Bazii,
Effect of effective dose (ED50) of olive oil on heart and liver parameters in normal New-Zealand rabbits.
journal of kerbala university,
Volume 4, Issue 4, Pages 87-96
This study was carried out to investigate the effect of effective dose (ED50) of olive oil on some parameters related to cardiac and hepatic functions in normal rabbits .The effective dose (ED50) of olive oil was determined in this study by studying the dose response curve . Twenty five adult male rabbits were divided randomly into five equal groups (5/group) and were intubated orally for four weeks with four successive increasing daily doses of olive oil (0.2 , 0.5 , 0.75 and 1 ml/kg B.W) . Fasting blood samples were collected of 7,14,21 and 28 days of experiment to study the following parameters : Serum total cholesterol (TC) , Triacylglycerol (TAG) , high density lipoprotein (HDL-C ) and reduced glutathione (GSH) concentrations and Aspartate Transaminase (AST) activity .
The results revealed that oral intubation of male rabbits with different doses of olive oil for four weeks caused significant (p<0.01) decrease in (TC) and TAG) concentrations and (AST) activity with significant (p<0.01) increase in GSH and HDL-C concentrations .The (ED50 ) of olive oil was found to equal to 0.51 ml/kg B.W.