Author : H. Zmam, Ezat
Synthesis and Characterization new 2,5- di (1,3,4- Thiadiazole)derivatives from 2,5- Thiophene Dicarboxylicacid
journal of kerbala university,
2008, Volume 4, Issue 4, Pages 77-80
New 2,5-di-(1,3,4-thiadiazole) derivatives of thiophene are prepared .reaction of 2,5-thiophene dicarboxylic acid with excess thionyl chloride formed compound (1),then treatment with hydrazine gives thiophene-2,5-dicarbohydrazine (2).A number of prepared arylisothiocyanate was reacted with compound (2) leads to form thiosemicarbazide derivatives (3),(4) and (5) .The last compounds are addition to Conc.sulfuric acid at 0Co with continues stirring so as to form 2,5-di-(1,3,4-thiadiazole) derivatives (6),(7) and (8) .The course of the reactions as well as the purity of products were monitored by means of T.L.C. Identification of products were achieved by elemental analysis) C.H.N), IR spectroscopy and 1HN.M.R.