ISSN: 1813-0410

Author : A. Faysel Al-Kufy, Dafer

Measuring MDA & GSH as Biomarkers for Oxidative Stress in Bladder Cancer Patients

Dafer A. Faysel Al-Kufy

journal of kerbala university, Volume 5, Issue 1, Pages 127-131

The aim of this study was to evaluate the oxidative stress in bladder cancer. Thirty bladder cancer patients of ages 66.4±14.2 years and, 33 healthy individuals of ages 61±3.8 years used as a control group were enrolled. The concentrations of malondialdehyde (MDA), reduced glutathione (GSH) were measured in sera of patients and the control group. The results analyzed by ANOVA analysis don’t exhibit a significant elevation for MDA concentration, while seen a significant (P<0.005) decrease for GSH concentration were indicated in the group of patients when compared with those of the control group.
Smoking was found to increase significantly (P<0.005) the levels of MDA and decrease significantly (P<0.005) the levels of GSH in the group of patients when compared with healthy individuals.
MDA levels were illustrated to increase significantly (P<0.001) in patients of current smoking and significant (P<0.005) decrease for GSH levels when compared with control group.