ISSN: 1813-0410

Author : ABID MAHDI, ELHAM


SIGNIFICANT CHANGES IN SERUM COPPER AND ZINC LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS

ELHAM ABID MAHDI

journal of kerbala university, 2009, Volume 5, Issue 2, Pages 207-212

objective of this study was to measure the alterations in two of important serum trace elements, including zinc (Zn++) and copper (Cu++), in patients with rheumatoid arthritis (RA) in AL-Hakeem hospital in Najaf city. In the study, serum trace elements were determined by using Atomic Absorption Spectrophotometer in sera of patients with RA (n=22), and statistically compared with healthy individuals (n=12). Serum Cu++ concentration was found significantly higher in patients group than those of healthy individuals (29.06±3.78 and 20.74 ±4.30 µmol/L, respectively) (p<0. 01). In contrary, Zn++ levels were lower in patients (7.78±4.41 µmol/L and 13.55±6.00 µmol/L, respectively) according to the healthy subjects (p<0.05).
The present study indicate no significant changes between active RA group and non-active group patients copper when evaluated copper metal. But there was significant difference between two groups (p<0.0 5) for zinc metal. Additionally positive correlation between serum cu levels and disease duration, while the correlation between serum Zn levels and disease duration was negative.
Our results showed a considerable amount of evidence indicating that cu++ and zn++ may contribute in etiopathogeesis of RA disease and that serum (Zn++,Cu++)concentrations are altered in RA patients ,we suggest that potential role for Cu and Zn may cooperate in the development of the disease .