Author : Amore Jabbar, Shaima
Study the effect of acrylamide on some physiological and histological properties of rabbits kidney who drenched with Flavonoids that extracted from grape seeds
journal of kerbala university,
Volume 6, Issue 4, Pages 209-218
Acrylamide is a chemical that is produced for use in the manufacture of plastics as well as various other materials. Although acrylamide is used in making some food packing. Flavonoids are a group of more than 4000 polyphenolic compounds that occur naturally in foods of plant origin. Forty eight albino rabbits are divided in to three groups, G1 fed on basal diet ( control group ), G2 drenched with acrylamide 10% W/V at three doses weekly, and G3 drenched with acrylamide 10% and Flavonoids 40% W/V at three doses weekly. After 16 weeks we revealed significant increase ( P< 0.05, P<0.02 ) in plasma creatinine and uric acids in G2 as compared with G1 and G3, while there are no significant changing( P>0.05) between G1 and G3. In the other hand Kidney histological changes for G2 demonstrated acute nephrotoxicity and glomerular degeneration as compared with G1 and G3.