Author : Abdul Wahab Al- Dabbagh, Maha
Synthesis and characterization of PVA cyclic acetal derivative and study of its biological activity.
journal of kerbala university,
Volume 1, Issue 0, Pages 199-205
The aim of this work is the synthesis of new grafted PVA polymer with aderivative of L-ascorbic acid (pentulosono-ɣ-lactone-2,3-enedibenzoate).
To obtain this polymer, the 5,6-O-isopropylidene –L-ascorbic acid (2)was chosen , which was prepared from the reaction of L-ascorbic acid (1)as starting material with dry acetone in the presence of hydrogen chloride .The esterification of hydroxyl groups at C-2 and C-3 positions with excess of benzoyl chloride in dry pyridine was obtained compound(3). Hydrolysis for compound (3)in acetic acid(65%) gave the compound (4). Peroxidation of the product (4) with sodium periodate results an aldehyde (5), which was reacted with PVA polymer to give acetal derivative of PVA (6).
All these compounds were characterized by Thin layer chromatography (TLC) and FTIR spectra and some were characterized by (U.V-Vis) spectra, 1HNMR spectra and 13CNMR spectra.
The polymer & polymer metal complex were found to posses’ good antibacterial activity.