Author : E. Al-Gazalyally, Moaed
A study of high sensitivity c-reactive protein ,fibrinogen, troponin I and lipid profile in patients with acute myocardial infarction
journal of kerbala university,
Volume 8, Issue 1, Pages 145-151
This study was conducted on 70 patients with acute myocardial infarction (52 males ,18 females) and 30 (22 males,8 females) apparently healthy subjects were taken as control group from October 2010 till August 2011.Blood collected in coronary care unit at Merjan Teaching Hospital in Hilla city within 12 hours of myocardial infarction attack and all the subjects were fasting at time of sample taking. The patients were diagnosed as having AMI depending on positive troponin I tests ECG finding plus clinical features of AMI, The sera obtained from the patients were used to determine the effect of AMI on high sensitivity c-reactive protein (hsCRP),fibrinogen, troponin I, total cholesterol, high density lipoprotein-cholesterol (HDL-C), triglycerides (TGs),very low density lipoprotein-cholesterol (VLDL-C), and low density lipoprotein-cholesterol (LDL-C) concentrations. The results show a highly significant increase in high sensitivity c-reactive protein (hsCRP), fibrinogen, troponin I, total cholesterol, triglycerides, very low density lipoprotein-cholesterol and low density lipoprotein-cholesterol concentration (p<0.001), while highly significant decrease in high density lipoprotein-choleterol(p<0.001) in sera of patients group compared to control group, also the results of this study showed positive significant correlation (r = 0.30, p<0.01) between increment of hsCRP and fibrinogen in patients group on other hand positive
but not significant correlation (r =0.044, p<0.05 ) of the above two parameters in control group.
Conclusion: Acute myocardial infarction associated with elevation of acute phase proteins. .HsCRP
and fibrinogen combination can be used in prediction of early events of atherosclerosis and post
infarction complication and how to prevent them. Lipid profile and quantitive determination of cardiac troponin I are always advisable in post AMI.