ISSN: 1813-0410

Author : Ahmed Kadum AL-Jebory, Samah

Role of LPS extracted from Klebsiella pneumoniae in humoral immune response in rabbits

Samah Ahmed Kadum AL-Jebory

journal of kerbala university, Volume 8, Issue 4, Pages 190-194

Twenty five pyuria patients were diagnosed. They were associated with K. pneumoniae . LPS was extracted from this bacteria and intramuscular injected in the tested rabbits.The immune status was observed at the end of immunization period after four successive doses of LPS for four weeks and we found this antigen stimulate specific systemic and mucosal humoral antibody titers as well as to the significant increased (p ≤ 0.05) in the total protein concentrations at serum and mucosal secretions in tested rabbits, in addition to the significant increased (p ≤ 0.05) in the concentrations of IgG, IgA, IgM, C3 and C4 at rabbits sera , thus K. pneumoniae immunodominant epitope and the LPS antigen or toxin extracted from this bacteria induced the T independent immune response then stimulation of humoral immune responses at both systemic and mucosal levels in rabbits .