ISSN: 1813-0410

Author : Hana.A.K,


Study Of Histopathological Effect Of Staphylococcus aureus In Female Albino Mice

Zainab.R.Z; Salema.L.H; Hana.A.K

journal of kerbala university, Volume 9, Issue 1, Pages 85-94

This experiment was designed to study histopathological changes in internal organs: liver,spleen,heart,lung,kidney,intestine,stomach,pancreas,ovary,uterus,and oviduct of white female mice after ingectable with Staphylococcus aureus dose 1x106 ..Thirty white female mice aged from (one month-two months), and weighted from (25-30) grams, and this study was worked in Pthology departmentcollege of Veterinary MedicineBaghdad University/.The mice were randomely divided into 6equal groups. Group1 ingected intra mammary gland with 1x106 S.aureus & killed after 24 hr.Group2 injected intra mammary with 1x106. S.aureus & killed after48hr. Group 3 injected intra mammary with 1x106. S.aureus & killed after 72 hr. Group 4 injected intra mammary with 1x106 S.aureus & killed after one week. Group 5 injected intra mammary with 1x106. S.aureus & killed after two weeks. Group 6 injected with normal saline along the period of experiment and considered as control group. The histopathological findings for liver, kidney, spleen, stomach, intestine, pancrease, ovary, uterus, mammary gland and oviduct showed infiltration of mononuclear cell with the liver paranchyma &portal area and pancreas interstitial tissue of the kidney with perivascular lymphocytic cuffing &mild degeneration changes represented by acute cellular swelling of hepatocytes and epithelial cell lining .The cortical renal tubules.In addition to sever congestion &dilatation of central vein and sinusoid. In addition to coagulation material in the in the lumen and small abscess in the parenchyma & thrombus. Necrosis of the hepatocyte. Spleen showed lymphoid hyperplasia of white pulp with sever congestion of blood vessels with infiltration of neutrophil in the blood sinus and proliferation of megacarocyte. Lung showed edema with congestion of blood vessels & haemorrhge and infiltration of mononuclear cell in the alveoli wall and thickening of the alveoli septa. Heart showed sever congestion with heamorrhe &infiltration of poly morphonuclear cells (PMN, S) between muscle fibers and losse of muscle straight .Intestine &stomach showed sloughing of epithelial lining the mucosal layer with congestion of blood vessels & infiltration of (PMNS) diagnostic as chronic suppurative enteritis and gastritis. Ovary showed congestion of blood vessels with tiny aggregated abscess consist of dead and live neutrophil &tissue debris diagnosis as oophilitis. Uterus showed congestion of blood vessels with infiltration of neutrophl in wall of uterus &proliferation of endometritis layer diagnositic as endometrosis. Oviduct showed congestion of blood vessels with infiltration of neutrophil in the epithelial lining & proliferation of epithelial lead to stenosis. Mammary gland showed congestion of blood vessels, with infiltration of neutrophil between smooth muscle fiber &present of portentous material pink cooler in the lumen.