Author : A. Al-Dhalimi, Muhsin
journal of kerbala university,
Volume 9, Issue 2, Pages 126-134
Background: To evalute the state of some biochemical markers in sera of plaque psoriatic patients .
Aim : The aim of this study is to investigate the levels of inflammatory
markers(leptin,adiponectin,CRP,TNF-alpha,IL-6 and IL-10) in plaque psoriatic and control groups and their relationship with the clinical severity of psoriasis.
Patients and Methods:The study was conducted on sixty patients with plaque psoriasis and thirty apparently healthy individuals were taken as control group.The sera obtained from the blood were used to determine the level of leptin,adiponectin, TNF-alpha, IL-6,IL-10 and CRP concentrations in both groups by enzyme linked immunosorbant assay (ELISA) method. Also determine the Correlation of the inflammatory markers with The Psoriasis Area and Severity Index (PASI) was determined.
Results and Discussion: The results of the present study showed a significant increase(P> 0.05) in leptin, TNF-alpha, IL-6 and CRP concentration, and a significant decrease (P> 0.05) in adiponectin and IL-10 in sera of plaque psoriasis group compared with those of the control group.Also,the results of linear regression analysis showed a significant positive correlation of leptin(r = 0.81, p<0.05),TNF-alpha (r=0.74, p<0.05), IL-6 (r = 0.75, p < 0.05 ) and CRP (r = 0.79, p < 0.05) . Also ,show a significant decrease in correlation of adiponectin (r= - 0.43, p<0.05) and IL-10 (r= -0.74, p<0.05) with the Psoriasis Area and Severity Index (PASI).
Conclusion: There is a significant increase in levels of inflammation markers and significant decrease in markers of anti-inflammation in plaque psoriasis as compared to non psoriatic control group.Also ,we correlated them with the clinical severity of psoriasis.