ISSN: 1813-0410

Author : Mohammed Redaa, Dalia

Evaluation of Liver function in sera of patients with Epilepsy

Sura Ahmed Al-Emami; Dalia Mohammed Redaa; Haider Ridha Mohammed Saeed

journal of kerbala university, 2013, Volume 9, Issue 2, Pages 119-125

Background: patients with epilepsy on antiepileptic drug therapy deserve special consideration for the adverse effect on hepatic functions. Aim:the present study aims to evaluate the hepatotoxicity by drugs of patients with epilepsy through determination of liver function tests such as total protein, albumin, bilirubin, cholesterol, and liver enzymes (alkaline phosphatase, and amino transferases). Subjects: twenty four patients with epilepsy were studied and compared with twenty six healthy individuals. Results: significant elevation of liver enzymes activity{(ALP (p˂0.001), SGPT(p˂0.01),SGOT(p˂0.001)}, protein(p˂0.01) , albumin (p˂0.01), bilirubin(p˂0.001) and cholesterol(p˂0.05) concentrations were observed in the sera of patients with epilepsy in comparison with that of the control group. Also a significant positive correlation between the specific activity of alkaline phosphatase and albumin concentration was found in the present study in the sera of patients with epilepsy.