ISSN: 1813-0410

Author : M.Abd Al razak, Mustafa


Some Physiological and Blood Parameters result From Low and High Dose of Radioactive Iodine-131 .

Hisham .M.A.K.Al-Azzawi; Hassan M. Resen; Jameel M.Badi; Mustafa M.Abd Al razak

journal of kerbala university, 2011, Volume 7, Issue 4, Pages 34-41

This study was conducted at Al-Yarmouk teaching hospital / Nuclear Medicine Unit by selection of 10 patients which they have been administered with low doses of radioactive iodine-131I / RAI ( 6-18 mCi) and at Radiotherapy Nuclear Medicine institute by selection of 10 patients that they have been administered with high doses (100-150 mCi) . Both groups of patients were suffered from different thyroid diseases (different thyrotoxicoss and various thyroid carcinoma) .Blood samples were collected to perform two steps of tests ( thyroid hormones, liver enzymes, kidney function and blood picture ) before and after radioactive iodine administration . The values of serum creatinine and urea were shown a significant decreasing level (p≤o.o5) after high and low doses of administration with significant increasing level of serum potassium and sodium at low dose(p≤o.o5) when compared with the same values before RIA administration.
The results obtained shown a significant increasing level(p≤o.o5)of total bilirubin, indirect bilirubin, GOT and ALP for high dose and total bilirubin in low dose in a comparison to the control group.
The values of blood components shown a significant increase (p≤o.o5) Total Protein,Globulin and Bas% in high dose and Total Protein, Mon% and Eos% in low dose, also the results obtained shown a significant (p≤o.o5) decreasing levels of Lym% and MCHC in high dose and WBC, Neu#,Lym#,Neu%, MCV, RDW-SD and PLT in low dose when compared with the same value before RIA administration.
The values of thyroid hormones shown a significant increase values (p≤o.o5) of T4 hormone in high and low dose and T3 hormone in low dose with a significant decreasing values (p≤o.o5) of TSH hormone in high and low doses when compared with the same values before RAI administration.