ISSN: 1813-0410

Author : AL-Bazii,


Histological and physiological study about effect of chronic x-ray exposure on male rabbit brain

AL-Bazii; S.J; AL-Bazii

journal of kerbala university, Volume 9, Issue 4, Pages 228-234

The aim of this study was to evaluate the effect of x-ray exposure on some physiological parameters and pathological lesions in the brain on male rabbits .
Twenty male rabbits were randomly divided into two groups (10/group) control(C) and group exposed to 100kilorad (Cx) .After three months was showed there was a significant increase(p<0.05) in the Malondialdehyde (MDA)level and Ach esterase activity , significant decrease (p<0.05) in reduced glutathione (GSH) level in brain tissue and a significant increase (p<0.05) in MDA , glucose ,total cholesterol(TC) ,triacyglyserol (TAG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) in the serum and a significant decrease (p<0.05) in high density lipoprotein (HDL) and protein concentration in the serum group which exposed to x-ray compare with the control group .
The microscopical examination was shown in the Cx group brain tissue characterized by necrosis and congestion compare with control group . In conclusion , the 100kilorad x-ray exposure in male rabbits showed increase in the oxidative stress markers and Ach esterase activity in brain tissue and serum ,pathological lesions in the brain tissue of male rabbits .