Author : Abdel mahdi Kassim Altaee, Raeed
Evaluation of antidiabetic and antihyperlipidimic activity of aqueous extract of Iraqi propolis in alloxan induced diabetes mellitus in Wister Albino rat
journal of kerbala university,
Volume 10, Issue 1, Pages 88-94
The present study was undertaken to investigate the antihyperglycemic and antihyperlipidemic effects of aqueous extract of Iraqi propolis (AEIP) in alloxan-induced diabetic rats. Diabetes was induced in Wister rats by single intraperitoneal administration of alloxan monohydrate (150 mg/kg). Animals were divided into five groups (n=6) in each receiving different treatments. Graded doses (150mg/kg and 300 mg/kg) of AEIP were studied in alloxan-induced diabetic rats for a period of 28th days. Glibenclamide (600 μg/kg) was used as a reference drug. For histomorphological study of pancreas , the animals were killed after 28 days , routine haematoxylin and eosin stain. In alloxan-induced diabetic rats, the daily oral treatment with AEIP significantly recover the weight (p>0.01) with respect to the control group, also a significant reduction in blood glucose. Besides, administration of AEIP for 28th days significantly(p>0.01) decreased serum contents of total cholesterol, triglycerides, low density lipoprotein LDL and very low density lipoprotein VLDL whereas HDL-cholesterol was effectively increased. The histopathological studies also indicated that AEIP is effective in regeneration of insulin secreting β-cells. Studies clearly demonstrated that AEIP possesses hypoglycemic and antihyperlipidemic effects mediated through the restoration of the functions of pancreatic tissues and insulinotropic effect.