Author : AL Haydar, Muder
journal of kerbala university,
2015, Volume 11, Issue 0, Pages 156-163
Flurbiprofen is related to nonsteroidal anti-inflammatory drugs. The aim of this study is to investigate use of almond oil as enhancer to increase drug skin penetration. Five selected formulas of flurbiprofen gel with five different concentration of almond oil were prepared. Only one formula was prepared without almond oil. The prepared gels were evaluated for several physico-chemical parameters to justify their suitability for topical use. The in vitro drug release studies were carried out by using Franz cell diffusion apparatus across synthetic membrane. The permeation profile of various formulations also showed that the adding an enhancer in individual formula affected the permeation of the drug. Drug permeation increased with increased concentration of almond oil.