ISSN: 1813-0410

Author : Aziz Ahmed, Abdul


EFFECT OF HORMONAL CHANGES IN BLOOD AND OVARIAN FOLLICULAR FLUID ON SUBFERTILITY: A STUDY ON WOMEN SUBJECTED TO INTRACYTOPLASMIC SPERM INJECTION(ICSI)

Abdul Aziz Ahmed; Basima Sh. Al-Ghazali

journal of kerbala university, Volume 11, Issue 0, Pages 1-12

Sixty two infertile women with ovulatory cause of infertility (group A) who undergo ICSI were enrolled in the study . The study also includes 30 women with male cause of infertility, who also undergo ICSI and regarded as control group (group B). Both groups of women were subjected to controlled ovarian hyperstimulation methods . At the day of ovum pickup hormone analysis of blood and follicular fluid(FF) were done to measure estradiol (E2) , testosterone , leptin and antimullerian hormones (AMH) . Blood and FF leptin and testosterone levels were significantly higher ( P< 0.05) in group A women in comparison with group B while FF and blood AMH level were significantly lower( P< 0.05) in group A in comparison with group B. Blood and FF leptin, and testosterone levels were significantly higher ( P< 0.05) group A women with BMI equal or more than 25kg/m² in comparison with group A women with BMI less than 25kg/m² . Blood and FF estradiol and AMH level were significantly higher (P< 0.05) in group A women aged 17 – 29 years in comparison with group A women aged 30 – 42 years. Blood and FF testosterone and leptin levels were significantly higher (P< 0.05) in group A women with polycystic ovarian syndrome (PCOS) in comparison with group A with non PCOS . There were significant correlations between blood and FF leptin, E2, and AMH levels in group A. There were also significant correlations between blood testosterone and AMH , and between blood E2 and AMH in group A . There were a significant correlation between FF testosterone and E2, between FF testosterone and AMH, between FF testosterone and leptin, and between FF estradiol and AMH of group A women .