ISSN: 1813-0410

Author : K. Mahmmod, Maha

Synthesis and characterization of new 2-Substituted Tetracycline derivative using -D-fructopyranose

Maha K. Mahmmod

journal of kerbala university, 2015, Volume 11, Issue 2, Pages 106-112

derivative of tetracycline at position 2 has been synthesized via way involved treatment of 1-chloro diacetone fructose with tetracycline to give derivative (IV), then the protected groups were removed using diluted acid. The Structures of the prepared compounds were elucidated on the basis of UV, FTIR and 1H-NMR spectral data which agreed with the proposed structures. The solubility studies proved that the new derivative of tetracycline be more soluble in polar solvent compared than free drug