Author : Ali Hussein AL-LBAN, Abbas
journal of kerbala university,
2016, Volume 12, Issue 1, Pages 240-253
To evaluate the effects of platelet rich plasma (PRP)on cutaneous regeneration and wound healing in both fixed and movable regions in horses, the present study was undertaken, under local anesthesia a full thickness square incision were done in the back of animals (fixed incision)and the longitudinal full thickness were done in the neck region (movable incisions). The fixed incisions injected 1 cm far from the incision’s edges with 0.1 ml of autologes PRP while the control group injected with normal saline only and by same manner the movable incision is treated besides that suturing is applied too. Our results showed that PRP lowered excessive development of granulation tissue and showed wound healing at 1, 2 and 3 weeks after wounding based on the histopathological results, there were re- epithelialization of epidermis, complete healing which characterized by regular arrangement of profuse fibrosis and scattered inflammatory cells, formation of new blood vessels and profuse collagen and fibrosis when compared with control group. We conclude from the current study that the single application of PRP for the treatment of the movable and fixed cutaneous wounds has increased the healing rates and adequate formation of granulation tissue as well as enhance angiogenesis in the beginning stage of the repair process.