ISSN: 1813-0410

Author : Mahmood Hameed, Falah


Evaluation of Two General Anesthetic Regimes by Use Xylazine and Ketamine with atropine and diazepam in Rabbits

Jassim M. Khalaf Albozachri; Falah Mahmood Hameed; Hayder Mohammed

journal of kerbala university, 2017, Volume 13, Issue 1, Pages 22-30

The present study was assigned to evaluate and compare two regimes of general anesthesia in rabbits. Twelve adult local breed rabbits from both sexes weighing (1.1-1.6( Kg. were divided equally into two groups each group consisted of six animals. Group(A) was injected intramuscularly by atropine1% at a dose 0.5mg/kg B.W as premedication, after 10min. the animals were injected xylazine 2% and ketamine hydrochloride 10% at a dose of 10 mg/kg, 50mg/kg B.W, respectively. Group(B) were injected intramuscularly by diazepam 10% at a dose 1mg/kg B.W. as premedication, after 10min. the animals were injected as same in group (A). The results of the physiological parameters of the self control at the period of zero time concerning heart rate, respiratory rate and rectal body temperature in group(A) were 147.3±0.577beats/minute; 130±0.577 breath/minute; 38.1±0.577 ºC respectively, while in group(B) were 151.6±0.57 beats/minute; 153.3±0.57 breath/minute; 38±0.57 ºC respectively. The results of physiological parameters at periods 10, 20, 35, 50, 65, 80, and 95minutes in group(A) were 154.1±5.77; 144.6±0.577; 128±0.577; 132.2±0.64; 128±0.577; 124.1±0.577; 132.6±0.577 beats/minute; 47.8±0.577; 47.6±0.577; 41.6±0.577; 39.3±0.577; 41.3±0.577; 39 ±0.577; 47±0.577 breath/minute; 39±0.577; 38.9±0.577; 38.5±0.578; 38.1±0.577; 37.8 ±0.577; 37.5±0.577; 37.2±0.577 ºC, while in group(B) were 157.5±0.57; 150±0.57; 150.6±0.57; 153.3±0.57; 153.8±0.57; 151.7±0.33; 152±0.57 beats/minute; 54±0.57; 49±0.57; 43.3±0.57; 42.3±1.73; 42.8±2.3; 45.6±0.57; 47.6±0.57 breath/minute; 38.8±0.57; 38±0.57; 37.6±0.57; 36.6±0.58; 36.5±0.57; 35.9±0.57; 35.9±1.15 ºC. The results of biochemical tests of GPT and GOT at zero time (self control) in group(A) were 53.1±0.577; 120.6±0.577 U/L, while in group(B) were 51.1±0.57; 118.8±0.57 U/L respectively, and the results at periods 20, 50, 95minutes and 24hours in group(A) were 44.1±0.577; 47.6±0.577; 65.1±1.186; 78.5±0.577 U/L, 109.5±0.577; 96.6±3.52; 109.3±1.154; 141±0.577, while in group(B) were 45.5±0.57; 42.1±0.57; 48±0.57; 69.1±0.57 U/L, 119±0.57; 111±0.57; 110±1.73; 139.8±0.57 U/L, respectively. The conclusion of this study investigate that the induction time, surgical time and recovery time in group(A) and group(B) were 5.8±0.577; 5.1±1.15; 56.6±0.577; 51.5±0.577; 71.6±0.577; 95.3±1.15minutes respectively in which the surgical time was enough for the most of surgical interference, while the induction time and recovery time were smooth in both group when comparison with another anesthetic regimes. From our results it may concluded that use of atropine with xylazine and ketamine exceptional from use diazepam with xylazine and ketamine.